Morphine is converted by hepatic metabolism to normorphine with a half-life of 2 to 4 hours. Morphine is a naturally occurring narcotic analgesic obtained from the poppy plant, Papaver somniferum. The ratio may fall below 1.0 after 24 hours, and after 30 hours, only morphine may be detected. If codeine is ingested, the ratio of codeine to morphine generally exceeds 1.0 in urine during the first 24 hours. Codeine is converted by hepatic metabolism to morphine and norcodeine with a half-life of 2 to 4 hours.
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